Wilder, who was tied for the lead after Round 1, fired a 1-under 70 to take a one-shot lead over Rob Simmons, Uly Grisette and Conor Richardson. Simmons had shared the first-round lead with Wilder before shooting an even-par 71 Friday.
On a day that could be classified as moving day, the first-round leaders were able to remain relevant despite a number of solid rounds.
Grisette paired a first-round 69 with a 66 Friday while Richardson went low, firing a 6-under 65 in Round 2.
Nicholas Reach shot 64 Friday and sits in a sixth-place tie along with three other players, including Michael Cromie, who shot 66 in the second round.
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Three-time U.S. Mid-Am champion and 2005 Azalea winner Nathan Smith moved up to a tie for 17th after shooting a second-round 69.
Wales native Rhys Enoch followed up a tough first round with a two-under 69 and is tied for 38th.
Dallas Cowboys quarterback, who played with Tiger Woods in the recent Pebble Beach Pro Am improved on his opening-round 77 with a 1-over 72.
Play continues with the third round beginning Saturday morning. Click here for the Saturday pairings.
